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NBC: Why many MS patients like Christina Applegate are misdiagnosed

Doctors say nearly 1 in 5 MS diagnoses may later be reversed, and Applegate says her treatment changes prompted the review.

  • On Tuesday, Actor Christina Applegate announced she was misdiagnosed with multiple sclerosis after years of believing she had the condition, sharing the news on her podcast, MeSsy.
  • Experts describe multiple sclerosis misdiagnosis as "fairly common" because no single test confirms the condition, and symptoms often mimic other autoimmune or neurological disorders.
  • Research indicates that between 15% and 20% of patients diagnosed with multiple sclerosis do not actually have the condition, with studies showing misdiagnosis rates ranging from 5% to 41%.
  • Dr. Robert Brumel of the Cleveland Clinic advises patients to seek a second opinion if concerned, noting that advanced MRI sequences can help differentiate lesions from other conditions.
  • Applegate stated she is "back at square one" regarding her health, as doctors launch an investigation to determine the cause of her debilitating symptoms since 2021.
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Christina Applegate isn't alone. Multiple sclerosis is misdiagnosed in nearly 1 in 5 cases

Christina Applegate's multiple sclerosis misdiagnosis isn't uncommon. Nearly one in five people who are told they have MS later learn that they don't. Here's why.

·Pittsburgh, United States
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Five years after her diagnosis, Christina Applegate learns that she doesn't seem to suffer from multiple sclerosis. She shares the fate of misdiagnosis with stars like Lucy Liu, Kylie Minogue or Halle Berry.

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USA Today broke the news in New York, United States on Tuesday, October 20, 2026.
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