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NBC: Why many MS patients like Christina Applegate are misdiagnosed

Experts say about 15% of MS diagnoses are later overturned, and Applegate says she still does not know what is causing her symptoms.

  • On Tuesday, Actor Christina Applegate announced she was misdiagnosed with multiple sclerosis after years of believing she had the condition, sharing the news on her podcast, MeSsy.
  • Experts describe multiple sclerosis misdiagnosis as "fairly common" because no single test confirms the condition, and symptoms often mimic other autoimmune or neurological disorders.
  • Research indicates that between 15% and 20% of patients diagnosed with multiple sclerosis do not actually have the condition, with studies showing misdiagnosis rates ranging from 5% to 41%.
  • Dr. Robert Brumel of the Cleveland Clinic advises patients to seek a second opinion if concerned, noting that advanced MRI sequences can help differentiate lesions from other conditions.
  • Applegate stated she is "back at square one" regarding her health, as doctors launch an investigation to determine the cause of her debilitating symptoms since 2021.
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abc 13 Houstonabc 13 Houston
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Why MS can be hard to diagnose, after Christina Applegate reveals misdiagnosis

Five years after revealing she was diagnosed with MS, actress Christina Applegate said she was misdiagnosed. Doctors explain why the condition can be hard to confirm.

·Houston, United States
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USA Today broke the news in New York, United States on Tuesday, October 20, 2026.
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