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Innate Immune System Variations Determine Vaccine Side Effects

Researchers found that stronger pre-vaccination interferon activity predicted more temporary side effects, and a second dose intensified innate immune responses in 51 volunteers.

Summary by News Medical
Redness and pain at the injection site, fever, fatigue or headaches: vaccines can cause side effects, but their frequency and severity vary considerably from person to person.

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Right

Why do some people react more strongly to an mRNA vaccination against Covid-19 than others? Researchers from Geneva have found a possible reason for this: It is therefore crucial how active the immune system is before the vaccination is administered.

·Vienna, Austria
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Lean Right

Why some people get fever after the Covid vaccination and others hardly feel anything: Geneva researchers see the cause in the already active immune system. The findings could change future vaccines.

·Vienna, Austria
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Why COVID-19-mRNA vaccinations cause significantly more transient symptoms in some people seems to depend on the immune state before vaccination. A combination of longitudinal data from vaccinated patients and mouse experiments combines stronger reactions with interferon signals, antibodies and activated monocytes. The findings could help to develop vaccines with lower reactiveness without equate strong complaints with better protection. Geneva …

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Kurier broke the news in Vienna, Austria on Thursday, September 17, 2026.
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