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Mixed Results for Adjuvant Pembro in Endometrial Cancer

Summary by Medscape
BARCELONA, Spain — New phase 3 findings revealed that most patients with newly diagnosed high-risk endometrial cancer did not benefit from receiving adjuvant immunotherapy alongside chemotherapy following surgery with curative intent. In the ENGOT-en11/GOG-3053/KEYNOTE-B21 trial, adding pembrolizumab to adjuvant chemotherapy did not improve disease-free survival in the “all-comer” intention-to-treat population. However, in prespecified subgroup …

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MedscapeMedscape

Mixed Results for Adjuvant Pembro in Endometrial Cancer

BARCELONA, Spain — New phase 3 findings revealed that most patients with newly diagnosed high-risk endometrial cancer did not benefit from receiving adjuvant immunotherapy alongside chemotherapy following surgery with curative intent. In the ENGOT-en11/GOG-3053/KEYNOTE-B21 trial, adding pembrolizumab to adjuvant chemotherapy did not improve disease-free survival in the “all-comer” intention-to-treat population. However, in prespecified subgroup …

·United States
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DataemiaDataemia

Mixed Results for Adjuvant Pembro in Endometrial Cancer

Phase 3 trial results showed that adding pembrolizumab to adjuvant chemotherapy did not improve disease-free survival in most patients with high-risk endometrial cancer. However, patients with mismatch repair-deficient tumors did benefit significantly from immunotherapy. The study included over 1,000 patients with curative surgery, and those in the dMMR subgroup showed a higher disease-free survival rate with pembrolizumab. While the overall res…

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