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Key path to Alzheimer's-like brain damage starts outside the brain
Removing peripheral dendritic cells cut brain T cells and preserved cognition in mice, suggesting Alzheimer’s damage may begin outside the brain, researchers said.
Immune cells that normally protect the body from damage by attacking foreign or infected cells are found in the brains of patients with Alzheimer's disease and related disorders at much higher levels than in healthy brains. The cells appear to contribute to neurodegeneration, but where they come from and how they are primed to accumulate in the brain was not known.