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Ketamine: What to know about the sedative drug some college students are using recreationally
Medical use is expanding as officials warn the drug can cause hallucinations, dependence and sexual assault risk.
With its dueling profile, the anesthetic ketamine has made headlines in recent years as both a psychoactive club drug and a promising medical treatment for depression and substance use disorder.
The Food and Drug Administration approves ketamine for anesthesia to block pain and cause unconsciousness, while doctors prescribe it off-label for conditions including PTSD and depression.
New York University researcher Joseph Palamar told The New York Times that even on small doses, users feel detached from emotions, while higher doses cause immobility, sedation, and a dissociative state called a "k-hole."
Under federal law, ketamine is classified as a Schedule III drug, though it faced scrutiny following Friends actor Matthew Perry's 2023 death and reports of billionaire Elon Musk using it to treat depression.
Long-Term abuse carries risks including poor memory, liver or kidney dysfunction, and bladder syndrome, while mixing alcohol with ketamine increases sedative effects; additionally, the substance has been used to facilitate sexual assault.