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Joe Manganiello Spent 7 Years Anticipating His Death During Debilitating Autoimmune Disease Battle

The actor says the illness caused 60-pound weight loss, emergency intestinal surgery and mental health struggles that inspired his memoir Bloodlines.

  • Actor Joe Manganiello reveals in his new memoir, 'Bloodlines,' that he battled a mysterious, undiagnosable autoimmune illness for seven years. Ahead of the October 13 release, the 49-year-old told People, "I can't believe I'm alive," saying he feels "reborn" after his recovery.
  • Starting shortly after his 2015 marriage to Sofia Vergara, Manganiello experienced debilitating symptoms including severe abdominal pain, rashes, and fatigue that left him unable to walk. The actor lost 60 pounds and underwent emergency surgery in 2016 to remove part of his intestines.
  • Turning to hydrocodone and fentanyl patches despite his 13 years of sobriety, Manganiello struggled to manage chronic pain. He credited adopting a five-pound chihuahua named Bubbles with saving his life during periods of suicidal ideation.
  • In the book, Manganiello alleges his marriage to Vergara became "devoid of any emotionality whatsoever" amid his illness. He also claims Vergara ridiculed his adoption of Bubbles and refused to hug him when he begged for an embrace.
  • Now symptom-free and engaged to actress Caitlin O'Connor, Manganiello disputes Vergara's previous claims that their 2023 divorce stemmed solely from conflicting views on having children. Vergara has not publicly addressed these specific accusations from his memoir.
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Lean Left

According to what the actor narrated in his memoir, Sofia Vergara did not support him enough and ridiculed the link he had with his dog.

·Los Angeles, United States
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Joe Manganiello's feud with Sofia Vergara is reaching its peak, as the actor makes new revelations about their divorce and his illness.

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The actor will release his memoirs on October 13th

·Madrid, Spain
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Detroit Free Press broke the news in Detroit, United States on Wednesday, October 7, 2026.
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