It takes two to TANGO: New strategy to tackle fibrosis and scarring

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Other: Daniel Hogan

It takes two to TANGO: New strategy to tackle fibrosis and scarring

A study has now successfully controlled the effects of collagen hypersecretion at the cellular level. The experimental treatment consists of designer peptides which interrupt the interaction between TANGO1 and cTAGE5, two proteins important for collagen secretion. Experiments with patient-derived human cells and zebrafish showed the peptides are effective, non-toxic, and their effects reversible. The results pave the way for the development of n…