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Toronto man’s HIV no longer detectable after bone marrow transplant

Doctors say the patient is off antiretroviral therapy after a 2021 transplant, and only 10 people worldwide have reached this milestone.

  • On Saturday, April 25, 2026, researchers announced a Toronto man is in prolonged HIV remission after receiving a stem cell transplant from a donor with natural immunity, potentially becoming the first Canadian cured of the virus.
  • Dr. Sharon Walmsley, director of the HIV Clinic at Toronto General Hospital, has treated the patient since his 1999 HIV diagnosis; he required a 2021 bone marrow transplant after developing aggressive leukemia, offering a rare chance for a "double cure."
  • Clinicians used a donor with a CCR5 gene mutation, which blocks HIV from entering immune cells; Dr. Jonas Mattsson, director of the Hans Messner Allogeneic Transplant Program at Princess Margaret Cancer Centre, oversaw the procedure.
  • The patient stopped antiretroviral therapy in July 2025 and has remained in "sustained remission" with undetectable viral loads for nearly 10 months; doctors note he must test negative for 20 more months to be confirmed cured.
  • Globally, only 10 patients have achieved this milestone, and experts emphasize that stem cell transplants remain too risky as a standard HIV treatment; this success provides insights for developing safer cures for the 41 million people living with HIV.
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37 Articles

Winnipeg Free PressWinnipeg Free Press
+27 Reposted by 27 other sources
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Breaking News, Sports, Manitoba, Canada

·Winnipeg, Canada
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The Toronto Star broke the news in Toronto, Canada on Saturday, April 25, 2026.
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