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HPMC gel used in eye surgery restores sight to people with untreatable hypotony, scientists say

Seven of eight patients regained sight after about 12 months of fortnightly hydroxypropyl methylcellulose injections at Moorfields, offering a safer alternative to toxic silicone oil treatment.

  • Moorfields Eye Hospital, London used repeated injections of low-cost HPMC gel to restore sight in patients with a rare untreatable condition, supported by Moorfields Eye Charity.
  • Affecting about 100 people in the UK each year, hypotony causes abnormally low eyeball pressure that alters eye shape and can lead to blindness without treatment.
  • The pilot, published in the British Journal of Ophthalmology, treated eight patients with fortnightly HPMC injections and restored eye shape and sight in seven patients after 12 months.
  • Moorfields has treated 35 hypotony patients to date and Mr Harry Petrushkin said the "results are holding up" while applying for large clinical trial funding.
  • Unlike silicone oil, the gel HPMC is transparent and clinicians say it could potentially help hundreds or even thousands of people in the UK.
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Experts use ‘filler’ treatment to restore sight in people with rare condition

The new treatment can help with hypotony – which affects about 100 people in the UK each year.

·London, United Kingdom
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Daily Mirror broke the news in London, United Kingdom on Monday, January 12, 2026.
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