Study Identifies Initial Cellular Events in Autoimmune Kidney Inflammation

Early Drivers of Autoimmune Kidney Damage Identified, Opening Door to Targeted Treatment

Researchers uncovered how injured kidney cells recruit immune cells that worsen inflammation and demonstrated an experimental antibody strategy that reduced kidney damage in mice.

Study identifies initial cellular events in autoimmune kidney inflammation

When immunity works well, the body steers clear of infection and disease. However, when the immune system goes awry, healthy cells can often end up in the firing line.

Curbing the neutrophil surge: New treatment offers hope for autoimmune diseases

When immunity works well, the body steers clear of infection and disease. However, when the immune system goes awry, healthy cells can often end up in the firing line. This can occur in autoimmune diseases like anti-neutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis, a kidney disease in which ANCAs trigger destructive inflammation. However, there has been little information about the sequence of events associated with the early…

How Infection Signals Push Kidney Filter Cells Into Leaks, Damage, and Cell

New research shows that sustained activation of the innate immune receptor TLR4 in podocytes triggers a reversible leak in the kidney filtration barrier, shedding of nephrin, and eventually apoptotic cell death through distinct signaling pathways.