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Chronic Alcohol Use Profoundly Alters Gene Expression in the Brain's Reward System

Study finds chronic alcohol use causes region-specific gene changes in the endocannabinoid system, with CB1 rising up to 125% and CB2 decreasing by about 50%, influencing relapse risk.

Summary by News Medical
Chronic alcohol consumption profoundly alters gene expression in key brain regions involved in reward, impulse control, and decision-making, according to a study led by researchers at the Institute for Neurosciences, a joint center of Miguel Hernández University of Elche (UMH) and the Spanish National Research Council (CSIC).

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Medical Xpress broke the news in on Monday, February 9, 2026.
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