Colorectal Cancer in Younger Patients Shows Distinct Cellular and Gene-Activity Patterns

Single-Cell Analysis Reveals Distinct Biology of Early-Onset Colorectal Cancer

An atlas of more than 850,000 nuclei revealed distinct cellular and genetic features in early-onset colorectal cancer, including changes associated with aggressive tumor behavior and poorer outcomes.

Colorectal cancer in younger patients shows distinct cellular and gene-activity patterns

Mass General Brigham researchers from the Gene Lay Institute of Immunology and Inflammation, along with researchers at Dana-Farber Cancer Institute and the Broad Institute, have uncovered biological clues to why colorectal cancer can behave more aggressively in younger people. Published in Nature Medicine, the study—the largest of its kind—lays a foundation for understanding age-associated differences in colorectal cancer and exploring future tr…

Colon cancer looks different in young people — and often more aggressive, a new study found

A new study found cellular differences between colon cancer tumors in younger and older patients.Sheila Alonso/Getty ImagesA new study explored the differences between tumors in younger and older colon cancer patients.Younger patients sometimes had more aggressive, treatment-resistant forms of colon cancer.Staying active, cutting down on processed foods, and getting screened are good ways to lower risk.People under 50 aren't only at a higher ris…

The rise of colon cancer among young people has been a mystery. Boston experts say they now have clues. - The Boston Globe

Boston researchers unveil the largest analysis of colorectal cancer tumor samples to date.

New atlas of colorectal tumors sheds light on why cancers in young people are more dangerous

Dana-Farber's Kimmie Ng discusses a landmark study mapping biological traits in early-onset colorectal cancer, offering potential future treatment targets.