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College Football Picks: Ohio State's Ryan Day Is an Old Hand when It Comes to Top-Five Matchups
Ohio State’s offense ranks second nationally in EPA per pass, while Kentucky is projected to upset Oklahoma behind a stronger balanced attack.
On Saturday, Oct. 17, No. 4 Ohio State faces Indiana in a top-five matchup at Memorial Stadium in Bloomington, the first top-five game ever hosted at the venue.
Indiana defeated Ohio State in last season's Big Ten championship game, propelling the program to its first national title. Ohio State head coach Ryan Day is 5-8 in top-five matchups since 2019.
Ohio State's offense ranks second nationally in EPA per pass, while Indiana's defense ranks 76th in opponent EPA per pass. The Hoosiers also rank 44th in net adjusted EPA per play.
Elsewhere, Kentucky is favored to upset Oklahoma following the Red River Rivalry, with analysts trusting the Wildcats, who rank better in adjusted EPA per play than the Sooners' struggling offense.
The race for conference championships and the College Football Playoff intensifies as the 2026 season progresses. Notre Dame leads the nation in net adjusted EPA per play ahead of facing the Cougars.