Cellular Delivery Route Uncovered That Could Improve Antisense Cancer Therapies

New study identifies key pathway for delivering antisense cancer drugs

Antisense oligonucleotides (ASOs) have been proposed as a therapeutic approach to shut down the production of faulty proteins in a wide variety of diseases, including cancer.

Cell-surface receptors guide antisense therapy to mutant KRAS in pancreatic cancer cells

Antisense oligonucleotides (ASOs) have been proposed as a therapeutic approach to shut down the production of faulty proteins in a wide variety of diseases, including cancer. In a study published in the Journal of Cell Biology (JCB), researchers at the Cancer Research UK Scotland Institute and the University of Glasgow identify a pathway by which ASOs enter cells and reach their targets, suggesting new ways to enhance the effectiveness of antise…

Cellular Delivery Route Uncovered That Could Improve Antisense Cancer Therapies

Antisense oligonucleotides (ASOs) can selectively switch off disease-causing genes, making them a promising therapeutic strategy for cancer and other disorders. But despite years of development, their success in oncology has been limited by a fundamental challenge: scientists have not fully understood how these short strands of DNA enter cells, escape intracellular compartments, and reach their RNA targets. A new study published in the Journal o…