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BeOne Medicines Announces New Phase 3 Survival Data Reinforcing Benefit of ZIIHERA-Containing Regimens in First-Line HER2+ Gastroesophageal Cancer

The second interim analysis showed a statistically significant overall survival benefit, and the regimen kept a manageable safety profile in 914 patients.

Summary by Financial Post
SAN CARLOS, Calif. -- BeOne Medicines Ltd. (Nasdaq: ONC; HKEX: 06160; SSE: 688235), a global oncology company, today announced positive topline results from the second interim analysis (IA2) of the Phase 3 HERIZON-GEA-01 trial evaluating ZIIHERA® (zanidatamab), in combination with chemotherapy, with and without TEVIMBRA® (tislelizumab), as first-line treatment for HER2+ locally advanced or metastatic gastroesophageal adenocarcinoma (GEA). At IA2…

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Results provide additional evidence for the overall survival benefit of treatment with TEVIMBRA plus ZIIHERA and chemotherapy in HER2-positive GEA. ZIIHERA plus chemotherapy demonstrated a statistically significant overall survival benefit in the second interim analysis of the HERIZON-GEA-01 study. SAN CARLOS, Calif.–(BUSINESS WIRE)– BeOne Medicines Ltd. (Nasdaq: ONC; HKEX: 06160; SSE: 688235), a […]

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jazzpharma.com broke the news on Monday, August 31, 2026.
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