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A toxin with a useful twist: Diphtheria fragment merges lipid vesicles at neutral pH

Summary by Phys.org
Researchers from the SNI network have discovered a novel way to fuse lipid vesicles at neutral pH. By harnessing a fragment of the diphtheria toxin, the team achieved vesicle membrane fusion without the need for pre-treatment or harsh conditions. Their work, recently published in Communications Chemistry, opens the door to new applications in lab-on-a-chip technologies, biosensors, and artificial cell prototypes.

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Researchers from the SNI network have developed a new method for fusing lipid vesicles at neutral pH. By using a portion of the diphtheria toxin, they achieve fusion of the vesicle membranes without pretreatment or harsh conditions. The work, which was recently published...

Researchers from the SNI network have developed a new method for fusing lipid vesicles at neutral pH. By using a portion of the diphtheria toxin, they achieve fusion of the vesicle membranes without pretreatment or harsh conditions. The work, which was recently published...

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Phys.org broke the news in United Kingdom on Wednesday, November 19, 2025.
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