Study Identifies Powerful Inherited Risk Factor for Lung Cancer
Researchers found carriers of an inherited EGFR mutation had a 60-fold higher lung cancer risk among nonsmokers, pointing to genetic testing for screening.
- On Thursday, a study published in Science found nonsmokers carrying the EGFR T790M mutation are 62 times more likely to develop lung cancer than those without it.
- Researchers traced the mutation to British and Irish settlers from about 200 years ago, explaining why it became concentrated in Southern Appalachia following a founder event and genetic bottleneck.
- Analyzing data from over 3 million research participants, investigators determined the mutation occurs in about 1 in 15,000 people nationally, but reaches 1 in 2,078 in Southern Appalachia.
- Dana-Farber Cancer Institute researcher Jaclyn LoPiccolo said the findings "raise the possibility that screening could also be dictated by inherited genetic risk."
- Scientists are now evaluating CT-based lung cancer screening in carriers while investigating why this mutation specifically affects lung cells and environmental factors like particulate-matter pollution.
20 Articles
20 Articles
Researchers find genetic answer to lung cancer in those who never smoked - Regional Media News
By Nancy Lapid Sept 18 (Reuters) - Today we feature an important genetic discovery that could help identify never-smokers at high risk of developing lung cancer. We also report on a study that aimed to make a common gynecological procedure less painful. GENE VARIANT HELPS PREDICT LUNG CANCER IN NON-SMOKERS Up to 20% of patients with lung cancer have never smoked. A new discovery could help doctors identify these high-risk individuals in advance …
Researchers find genetic answer to lung cancer in those who never smoked
By Nancy Lapid Sept 18 (Reuters) - Today we feature an important genetic discovery that could help identify never-smokers at high risk of developing lung cancer. We also report on a study that aimed to make a common gynecological procedure less painful...
A genetic analysis of 3.3 million people identifies the most potent inherited characteristic of lung cancer found so far
Inherited EGFR T790M Mutation May Raise Lung Cancer Risk 60 times in Nonsmokers, Study Finds
WASHINGTON: Scientists have identified an inherited genetic mutation that can raise a person’s risk of developing lung cancer by about 25 times, according to a new study of more than 3.3 million people. Among nonsmokers, the increase is even more dramatic, with the gene raising lung cancer risk some 60 times.For the new study, researchers analysed data from more than 3.3 million people who sent off a DNA sample to the ancestry and genetics compa…
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برس بيResearchers have reported that up to 20% of lung cancer patients have never smoked, suggesting that a rare genetic mutation could help identify and more closely monitor those at higher risk of developing the disease. A study analyzing data from over 3.3 million people in the 23andMe genetic database showed that a rare mutation in the epidermal growth factor receptor (EGFR) gene is associated with a significantly increased risk of lung cancer. C…
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