A process that traps extrachromosomal (ec)DNA in micronuclei during cell division could be the key to treating aggressive cancers characterized by high levels of ecDNA in their cells.
Aggressive tumors often have large amounts of ring-shaped DNA. If the rings could be eliminated from the nuclei of the cancer cells, the chances of survival of the patients would increase significantly, reports an international team led by Anton Henssen from the ECRC in "Nature Genetics...