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Cholesterol screening and treatment for younger adults, new guidelines suggest

The 2026 guidelines endorse the PREVENT-ASCVD risk calculator and call for lipid-lowering therapy for millions of Americans starting in their 30s to reduce lifetime heart disease risk.

  • On Friday, the American College of Cardiology and American Heart Association released updated guidelines urging adults to begin managing LDL cholesterol by age 30, down from the previous age 40 threshold.
  • The Predicting Risk of Cardiovascular Disease EVENTs, or PREVENT, calculator now enables clinicians to evaluate 30-year cardiovascular risk for adults ages 30 to 79, shifting focus from short-term to lifetime exposure.
  • New recommendations set LDL targets below 100 mg/dL for most adults, while guidelines now require everyone to undergo lipoprotein testing at least once to identify genetic risk factors routine screenings miss.
  • Dr. Steven Nissen, chief academic officer at Cleveland Clinic, praised the lifetime-risk focus while acknowledging statins may cause rare side effects like muscle pain, saying the guidelines "should have been" adopted earlier.
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It is recommended that adults over 30 years of age who have LDL levels above 160 mg/dL consider the use of statins

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Millions more people may need to start cholesterol-lowering medications as young as their 30s

Millions more adults should consider starting cholesterol-lowering medications earlier to reduce their risk of heart attack and stroke.

·Sacramento, United States
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What to know about the new cholesterol screening guidelines to prevent heart disease

Heart health experts released new guidance to help identify early risk factors for heart disease that go beyond tracking cholesterol numbers to prevent illness.

·Spokane, United States
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Healio broke the news in on Friday, March 13, 2026.
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