Metabolic pathways drive progression from pancreatic lesions to cancer

Metabolic pathways drive progression from pancreatic lesions to cancer

Pancreatic ductal adenocarcinoma is the most common type of pancreatic cancer and has a low five-year survival rate.

Researchers Identify Cellular Pathways That Drive Precancerous Lesions to Form Pancreatic Tumors

In a new study published in Nature Metabolism, researchers identified cellular pathways that can influence metabolic changes when cells progress from metaplasia to cancer. Their results could help researchers treat benign lesions before they become tumors.

Pancreatic Cancer Development Driven by NADPH Disruption

Researchers at the University of Michigan have uncovered metabolic pathways that explain how pancreatic cells transition from acinar-to-ductal metaplasia to pancreatic ductal adenocarcinoma (PDAC). The study, published in Nature Metabolism, detailed on how reduced production of a molecule central to biosynthesis and oxidative stress control called NADPH alters cellular conditions to favor cancer progression. By examining precancerous pancreatic …

Scientists Uncover Cellular Pathways Driving Precancerous Lesions to

Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest malignancies, notorious for its grim five-year survival rates and late-stage diagnosis. Despite substantial progress in understanding tumor biology, the molecular events driving the initial transformation from normal pancreatic tissue to malignant states have largely eluded scientific inquiry. A groundbreaking study recently published in Nature Metabolism offers fresh insight i…