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Mayo Clinic selects Dr. Matthew Callstrom as new president and CEO
The board cited his nearly 25 years at Mayo Clinic and his leadership in generative artificial intelligence and enterprise programs.
The Mayo Clinic Board of Trustees announced on Friday, Nov. 13, 2026, that Dr. Matthew Callstrom will become the next president and CEO, effective Jan. 1, 2027.
Callstrom succeeds Dr. Gianrico Farrugia, who led Mayo Clinic since January 2019 and oversaw major AI advancements and expansion projects during his eight-year tenure.
An interventional radiologist with nearly 25 years at Mayo, Callstrom directs Mayo Clinic Strategy and the Generative Artificial Intelligence program. Richard Davis, chair of the Board of Trustees, called him an "accomplished physician-scientist."
Mayo Clinic's bylaws require the top executive to be a physician with at least five years of voting staff membership. Callstrom will oversee the organization and Rochester campus, while Arizona and Florida CEOs manage their respective locations.
Callstrom aims to accelerate the translation of discovery into care at Mayo. He stated, "We're building AI into the fabric of Mayo," emphasizing integration of emerging technologies to empower physicians and extend patient impact.