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Lycorine Hydrochloride Suppress the Proliferation, Metastasis and Invasion of Esophageal Cancer by Targeting TRIM22 and Inhibiting the JAK2/STAT3, PI3K/AKT and MAPK/ERK Pathways

Summary by preprints.org
Background: Tumor metastasis and poor drug efficacy are two of the prominent causes of therapeutic failure in tumor patients. The underlying molecular mechanism requires further exploration and novel effective curative strategies are urgently needed. Nature is a rich source for novel drug discovery and Lycorine hydrochloride (Lyc.HCL) is a natural alkaloid with tremendous therapeutic potential. However, the molecular mechanisms of anti-tumor are…
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