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Innovative Mitochondrial Isolation for Osteoarthritis Transplantation: Safety Profiles and Localization Outcomes In Vitro and In Vivo

Summary by preprints.org
Osteoarthritis (OA) is the most common rheumatologic disease and a major cause of pain and disability in older adults. No efficient treatment is currently available. Mitochondrial dysfunc-tion in chondrocytes promotes the molecular dysregulation involved in OA pathogenesis, making transplant of mitochondria as a potential therapeutic targets for treating OA. Mitochondria were isolated from liver using a combining the procedure described by Prebl…
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