How Psychological Stress Can Trigger Arthritis Flares via an Inflammatory Pathway
Researchers traced stress-triggered joint flares to brown fat IL-6, and blocking β3-adrenergic or CXCR2 signaling stopped inflammation in mice.
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4 Articles
Science Writing, Oct 16 (EFE).- Psychological stress has long been associated with worsening symptoms and outbreaks in rheumatoid arthritis.Now, a team led by Japanese scientists has discovered one of the possible underlying mechanisms behind this association.The details are published this Friday in Science Advances magazine and researchers from the University of Chiba and several hospitals in Japan focus on responding to how psychological stres…
Researchers discover a stress response pathway that links brown fat and synovial fibroblasts to joint inflammation
How psychological stress can trigger arthritis flares via an inflammatory pathway
Psychological stress has long been associated with worsening symptoms in rheumatoid arthritis (RA). However, the underlying mechanism connecting psychological stress to the occurrence of joint inflammation has remained poorly understood. In particular, how psychological stress can trigger inflammation in joints that were previously affected, even after the disease has gone into remission, remains an important unanswered question.
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