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Gene yaks have could inspire new multiple sclerosis treatments
The Retsat gene mutation from Tibetan Plateau animals boosts myelin repair by increasing vitamin A metabolite ATDR, reducing disease severity in mice with MS-like symptoms.
- Research published by Professor Liang Zhang in Neuron shows the Retsat mutation aids myelin repair in mice, allowing it to regenerate "much faster and more completely" after injury.
- Scientists investigated the Retsat mutation, an evolutionary adaptation found in animals on the Tibetan Plateau, which helps maintain Brain function in low-oxygen environments.
- Mice with the mutation produced higher levels of ATDR in the Brain, increasing enzymatic activity that promotes production and maturation of myelin-producing oligodendrocytes.
- Zhang's study showed that mice with the Retsat mutation produced higher levels of ATDR, which decreased symptom severity and improved motor function in MS-like mice, suggesting new treatment avenues.
- Beyond physical repair, Zhang noted that mice carrying the Retsat mutation performed significantly better in learning and social behavior tests.
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Total News Sources29
Leaning Left5Leaning Right1Center8Last UpdatedBias Distribution57% Center
Bias Distribution
- 57% of the sources are Center
57% Center
L 36%
C 57%
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