Researchers at the Broad Institute of MIT and Harvard have developed a gene-editing treatment for prion disease that extends lifespan by about 50 percent in a mouse model of the fatal neurodegenerative condition.

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New gene-editing treatment extends lifespan in mice with prion disease

Researchers at the Broad Institute of MIT and Harvard have developed a gene-editing treatment for prion disease that extends lifespan by about 50% in a mouse model of the fatal neurodegenerative condition. The treatment, which uses base editing to make a single-letter change in DNA, reduced levels of the disease-causing prion protein in the brain by as much as 60%.

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Gene editing extends lifespan in mouse model of prion disease

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Ian Birkby

Researchers have developed a gene-editing treatment for prion disease that extends lifespan by about 50 percent in a mouse model of the fatal neurodegenerative condition. The treatment, which uses base editing to make a single-letter change in DNA, reduced levels of the disease-causing prion protein in the brain by as much as 60 percent. The work demonstrates that lowering levels of the prion protein improves lifespan in animals that have been i…

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Science Daily

Daniel Hogan

Investigators developed in vivo cytosine and adenine base strategies delivered by adeno-associated viruses to permanently modify the PRNP locus to achieve prion protein knockdown in the mouse brain. [Nature Medicine] Full ArticlePress Release

Stemwell Science News

In Vivo Base Editing Extends Lifespan of a Humanized Mouse Model of Prion Disease

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Base Editing Technique Extends Lifespan in Prion Disease Mouse Model

ecotopical.com

Researchers from the Broad Institute of MIT and Harvard have achieved a significant breakthrough in the battle against prion diseases through innovative gene-editing techniques. Their pioneering study demonstrated that by using base editing to introduce a precise alteration in the DNA sequence, they could extend the lifespan of mice afflicted with a humanized version of prion disease by an astonishing 50 percent. This achievement marks a crucial…

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Gene Editing Demonstrates Lifespan Extension in Mouse Model of Prion

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Gene editing extends lifespan in mouse model of prion disease 
By Allessandra DiCorato January 14, 2025 
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Gene editing extends lifespan in mouse model of prion disease 
A single-letter edit in DNA reduces levels of the disease-causing prion protein in the brain and could lead to a preventative, one-time treatment for the deadly neurodegenerative disorder. 
By Allessandra DiCorato
January 14, 2025 
Credit: Maria Nemchuk, Broad Co…

New gene-editing treatment extends lifespan in mice with prion disease

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