Scientists from the Kavli Institute of Delft University of Technology and the IMP Vienna Biocenter have discovered a new property of the molecular motors that shape our chromosomes. While six years ago they found that these so-called SMC motor proteins make long loops in our DNA, they have now discovered that these motors also put significant twists into the loops that they form.

Phys.org

United Kingdom

A new twist: The molecular machines that loop chromosomes also twist DNA

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Scientists have discovered a new property of the molecular motors that shape our chromosomes. While six years ago they found that these so-called SMC motor proteins make long loops in our DNA, they now discovered that these motors also put significant twists into the loops that they form. These findings help us better understand the structure and function of our chromosomes. They also provide insight into how disruption of twisted DNA looping ca…

Science Daily

Daniel Hogan

United States

A new twist: The molecular machines that loop our chromosomes also twist DNA

New research shows that SMC proteins loop and twist DNA consistently in both humans and yeast, impacting DNA structure and function, crucial for addressing genetic diseases. Scientists from the Kavli Institute at Delft University of Technology and the IMP Vienna BioCenter have uncovered a new property of the molecular motors that organize our chromosomes. Six [...]

Sci Tech Daily

DNA’s Secret Dance: How Molecular Machines Twist and Loop Life’s Code

Background The three-dimensional structure of the human genome is folded to form many loops, which are involved in some critical structural chromatin proteins. The DNA binding protein ccctc-binding factor (CTCF) anchors the chromatin loop. Most anchoring loops of CTCF junctions have t...

researchsquare.com

Integrating epigenome and sequence features for CTCF-mediated chromatin loop prediction using LightGBM

Researchers discovered a new property of the molecular motors that shape our chromosomes also twist DNA.

Tech Explorist

The molecular machines that loop our chromosomes also twist DNA

ecotopical.com

New research shows that SMC proteins loop and twist DNA consistently in both humans and yeast, impacting DNA structure and function, crucial for addressing genetic diseases. Scientists from the Kavli Institute at Delft University of Technology and the IMP Vienna BioCenter have uncovered a new property of the molecular motors that organize our chromosomes. Six […]

A new twist: The molecular machines that loop chromosomes also twist DNA

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