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World Health Organization recommends GLP-1 drugs as long-term obesity treatments

WHO advises GLP-1 drugs as part of comprehensive obesity care, noting fewer than 10% of eligible adults may access them by 2030 due to cost and supply constraints.

  • On Monday, the World Health Organization recommended GLP-1 drugs as a tool to manage obesity in adults, publishing guidance in JAMA defining long-term use as six months or more.
  • Regulatory approvals, including by the Food and Drug Administration, preceded the guidance drafted by a committee of obesity, pharmacology and public-health experts at the request of WHO member states amid debate in recent years.
  • GLP-1 drugs work by mimicking a hormone that signals fullness and reduce appetite to help people lose weight, while more than 890 million adults worldwide are obese and obesity causes 3.7 million deaths annually.
  • The recommendation is conditional, the WHO said, as benefits likely outweigh downsides but more long-term safety and efficacy data, plus lower prices, are needed to address access and pricing concerns.
  • In the U.S., one in eight adults report currently taking a GLP-1 drug amid the societal shift in obesity framing and WHO urging public-health coordination.
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A range of medicines, called GLP-1, effective against overweight and diabetes, could help fight obesity, according to WHO.

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GLP-1 drugs are "a powerful clinical tool" against obesity, said WHO on Monday, December 1. Globally, this disease affects more than a billion people. - Ozempic, Wegovy and Mounjaro: WHO recommends these treatments to fight obesity (Health and well-being).

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Scientific American broke the news in on Monday, December 1, 2025.
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