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Preliminary Data From FANSS Study Show Potential for ...
The Female Asian Nonsmoker Screening Study detected 13 lung cancers using a blood test combined with low-dose CT, showing a 1.3% detection rate in non-smoking Asian women, researchers said.
- At ESMO Asia 2025 in Singapore on Saturday, December 6, NYU Langone Health researchers and DELFI Diagnostics, Inc. will present preliminary FANSS data showing feasibility of screening non-smoking Asian women using blood-based fragmentomics and low-dose CT.
- The study enrolled Asian American women aged 40-74 with no smoking history, targeting a group that appears to face higher lung cancer risk without formal screening guidelines.
- Elaine Shum, MD, noted, `We enrolled 1,000 participants who underwent baseline LDCT, and 13 were diagnosed with invasive lung adenocarcinoma, a 1.3% detection rate`, with nine Stage IA cancers and ongoing follow-up for 14 Lung-RADS cases.
- The lab-developed FirstLook Lung test is designed to integrate with routine blood work, reporting a 99.8 percent negative predictive value but has not been cleared or approved by the FDA.
- Funded by DELFI Diagnostics and private philanthropy, FANSS uses cfDNA fragment patterns from whole-genome sequencing with the DELFI platform and low-dose CT to develop classifiers.
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