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Alzheimer’s Blood Tests May Be Misleading for People with Kidney Problems
Study of nearly 2,300 older adults found those with impaired kidneys and high neurofilament light chain had nearly double the dementia risk, highlighting kidney health's role in Alzheimer’s biomarkers.
- The journal Neurology reported that researchers found an association between impaired kidney function and higher blood levels of proteins linked to Alzheimer’s disease.
- Because kidneys remove blood toxins, researchers say healthy kidneys might delay dementia by filtering toxic brain-related proteins and clinicians should monitor kidney health when assessing biomarkers.
- The study measured Tau proteins, neurofilament light chain , and GFAP in nearly 2,300 dementia-free adults over about eight years, with researchers reporting elevated NfL linked to higher dementia risk in those with impaired kidneys.
- Clinicians may need to consider kidney function when interpreting Alzheimer’s biomarkers in blood, as the American Academy of Neurology’s news release warned patients with impaired kidney function might face higher dementia risk.
- At the same time, adjusted models showed people with failing kidneys and elevated Neurofilament light chain had nearly twice the dementia risk, but researchers' adjusted analyses found no independent link.
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Science DailyReposted by 
Knowridge Science Report
Knowridge Science ReportAlzheimer’s blood tests may be misleading for people with kidney problems
A large study found that people with impaired kidneys tend to have higher Alzheimer’s biomarkers, yet they don’t face a higher overall risk of dementia. For those who already have elevated biomarkers, kidney problems may speed up when symptoms appear. The findings show that kidney health can change how Alzheimer’s blood tests are read. Doctors may need to consider both organs to get a clearer picture.
·United States
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ABC FOX Montana+11 Reposted by 11 other sources
Poor Kidney Health Might Influence Dementia, Alzheimer's Risk
Key Takeaways
·Missoula, United States
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Total News Sources15
Leaning Left4Leaning Right2Center4Last UpdatedBias Distribution40% Left, 40% Center
Bias Distribution
- 40% of the sources lean Left, 40% of the sources are Center
40% Center
L 40%
C 40%
R 20%
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