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Want a Younger Brain? Keep the Muscle, Shed the Fat
A study of 1,164 adults found higher muscle mass and lower visceral fat-to-muscle ratio link to younger biological brain age, highlighting muscle preservation's role in brain health.
- Next week, Cyrus Raji, M.D., Ph.D., will present a study of 1,164 participants linking higher muscle mass and lower visceral fat-to-muscle ratio with younger-looking brains.
- Visceral fat, the deep belly fat, is linked to diabetes and high cholesterol, and increases inflammation that can affect the brain, while body mass index often masks fat distribution risk.
- An AI model trained on 5,500 MRIs calculated participants' brain age, finding an average brain age 56.04 and mean brain age gap 0.69 years using T1-weighted whole-body MRI.
- The team suggests MRI-AI endpoints could inform GLP-1 dosing and monitoring, as GLP-1 weight-loss drugs reduce visceral fat but may cause muscle loss, guiding trials that preserve muscle for brain health.
- Guidelines advise 150 minutes of aerobic activity weekly and strength training twice a week with eight to 12 reps, while elective full-body scan cost up to $5,000.
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37 Articles
37 Articles
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Coverage Details
Total News Sources37
Leaning Left5Leaning Right3Center8Last UpdatedBias Distribution50% Center
Bias Distribution
- 50% of the sources are Center
50% Center
L 31%
C 50%
R 19%
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