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One in Two People in the U.S. Is Affected by a Neurological Disease or Disorder
A systematic analysis shows 54% of Americans live with neurological conditions, with tension-type headache, migraine, and diabetic neuropathy most common, causing significant disability.
- On November 24, 2025, a systematic analysis found more than 180 million Americans, or 54%, live with a neurological condition, published by the American Academy of Neurology and IHME in JAMA Neurology.
- Improved survival and an aging population mean deaths from neurological disease declined by 15% while years lived with disability rose by 10% from 1990 to 2021.
- The researchers found the most common diagnoses were tension-type headache affecting 121.9 million, migraine 57.7 million, and diabetic neuropathy 17.1 million, with stroke causing the greatest disability at 20.9 million DALYs.
- The study found that neurological disorders caused 16.6 million DALYs in 2021, and the analysis called it an 'urgent call to action,' said American Academy of Neurology President Natalia S. Rost, MD, MPH, FAAN, FAHA.
- Using GBD 2021 data, researchers analyzed 36 neurological conditions in the U.S. with more than 17,000 collaborators, funded by the Bill & Melinda Gates Foundation.
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New analysis shows one in two people in the U.S. live with neurological conditions
One in two people in the United States, just over half of the population, is affected by a neurological disease or disorder, according to a new systematic analysis by the American Academy of Neurology and the Institute for Health Metrics and Evaluation published on November 24, 2025, in the journal JAMA Neurology.
·United States
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