Nicotinamide modulates gut microbial metabolic potential and accelerates recovery in mild-to-moderate COVID-19

Nicotinamide modulates gut microbial metabolic potential and accelerates recovery in mild-to-moderate COVID-19

Cellular NAD+ depletion, altered tryptophan metabolism and gut microbiome dysbiosis are associated with disease progression and unfavourable clinical outcomes in COVID-19. Here, we show that supplementing tryptophan metabolism with nicotinamide alleviates COVID-19 symptoms. We evaluate a 4-week intervention with a novel nicotinamide formulation (1,000 mg) in a prospective, double-blind, randomized, placebo-controlled trial in 900 symptomatic out…

Clinical trial finds faster recovery from COVID-19 through targeted use of high-dose vitamin B3 in the gut

Many patients suffer not only from respiratory symptoms due to their COVID-19 disease, but also from significantly reduced physical performance. A patent-protected tablet (CICR-NAM) developed at the University Hospital Schleswig-Holstein (UKSH), Campus Kiel, releases nicotinamide, a form of vitamin B3, specifically in the gut.

A special vitamin B3 tablet from Kiel helps covid sufferers to become more efficient again faster.

Nicotinamide Boosts Gut Microbes, Speeds COVID-19 Recovery

In a groundbreaking study poised to transform our understanding of COVID-19 recovery, researchers have unveiled the critical role of nicotinamide, a form of vitamin B3, in modulating gut microbial metabolism and hastening recovery among patients with mild-to-moderate COVID-19. This research, published in Nature Metabolism in 2025, draws attention to the interplay between micronutrients, the gut microbiome, and immune response dynamics during vir…