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Immunotherapy helps certain cancer patients avoid surgery: ‘We hope this is the future’

  • In 2020, Kelly Spill was diagnosed at age 28 with stage III rectal cancer in the United States and faced a standard treatment plan involving chemotherapy, radiation, and invasive surgery.
  • Before beginning chemotherapy, Spill was offered the chance to take part in a clinical trial that treated her cancer exclusively with the immunotherapy agent dostarlimab, which activates the body's immune response against tumors lacking proper mismatch repair and is gentler than conventional therapies.
  • The new study included 117 patients with mismatch repair-deficient cancers, and after six months, 80% who completed dostarlimab treatment avoided surgery, radiation, or chemotherapy with minimal toxicity.
  • Spill received 30-minute infusions every three weeks without adverse side effects, her tumor disappeared after nine treatments, and she has since carried additional children, preserving her fertility.
  • This immunotherapy trial shows promise in reducing invasive treatments for select patients with certain genetic mutations but requires larger studies to confirm long-term benefits and wider applicability.
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The Herald Scotland broke the news in Scotland, United Kingdom on Sunday, May 4, 2025.
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