Published 3 years ago

Messenger RNA expressing PfCSP induces functional, protective immune responses against malaria in mice

Summary by Ground News

In 2019, there were an estimated 229 million cases of malaria and 409,000 deaths globally. Worldwide, Plasmodium falciparum is the parasite species that causes the vast majority of deaths. The most advanced malaria vaccine is RTS,S, a first-generation product developed in partnership with WRAIR.

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Eurek Alert

mRNA vaccine yields full protection against malaria in mice

WRAIR scientists and partners developed an mRNA vaccine that protects against malaria in animal models. Malaria remains a large public health and economic burden worldwide as well as a danger to deployed Service Members. This vaccine uses mRNA accompanied by a lipid nanoparticle to prompt cells to code for circumsporozoite protein, which then triggers an immune response against malaria. The vaccine achieved high levels of protection in mice, enc…

3 years ago·Washington, United States

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Medical Xpress

mRNA vaccine yields full protection against malaria in mice

Scientists from the Walter Reed Army Institute of Research and Naval Medical Research Center partnered with researchers at the University of Pennsylvania and Acuitas Therapeutics to develop a novel vaccine based on mRNA technology that protects against malaria in animal models, publishing their findings in npj Vaccines.

3 years ago

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Sci Tech Daily

New mRNA Vaccine Provides Full Protection Against Malaria in Mice

Recent advancements allow for novel approaches against an old enemy. Scientists from the Walter Reed Army Institute of Research and Naval Medical Research Center partnered with researchers at the University of Pennsylvania and Acuitas Therapeutics to develop a novel vaccine based on mRNA technolo

3 years ago

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Nature

Messenger RNA expressing PfCSP induces functional, protective immune responses against malaria in mice

Human malaria affects the vast majority of the world’s population with the Plasmodium falciparum species causing the highest rates of morbidity and mortality. With no licensed vaccine and leading candidates achieving suboptimal protection in the field, the need for an effective immunoprophylactic option continues to motivate the malaria research community to explore alternative technologies. Recent advances in the mRNA discipline have elevated t…

3 years ago·United Kingdom

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