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Lisa Vanderpump's Nephew Sam Vanderpump Shares "End Stage" Liver Disease Diagnosis

  • On Monday, October 27, Sam Vanderpump revealed on Made In Chelsea he has irreversible end-stage liver disease and is being sent for a liver transplant assessment, saying, `We had a call from the doctors and I've got end-stage liver disease.`
  • Born with congenital hepatic fibrosis and polycystic kidney disease, Sam Vanderpump’s severe flu and asthma attack triggered sepsis, causing liver and kidney failure.
  • Remaining optimistic, Vanderpump said he is 'healthy now' and hopes to stay so until surgery, adding that expecting their first child with fiancée and model Alice Yaxley shaped his recent personal decisions.
  • The NHS Organ Donation service responded by praising Vanderpump for speaking out and urged people to join the donor register as thousands wait for transplants.
  • After becoming delirious, Vanderpump was rushed to Chelsea and Westminster Hospital, where doctors warned that arriving 24–48 hours later could have been fatal, with his fiancée's ambulance call likely saving his life.
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Metro News broke the news in London, United Kingdom on Tuesday, October 28, 2025.
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