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JCI Plasminogen activator inhibitor 1 promotes aortic aging–like pathophysiology in humans and mice
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JCI Plasminogen activator inhibitor 1 promotes aortic aging–like pathophysiology in humans and mice
Plasminogen activator inhibitor 1 (PAI-1), encoded by SERPINE1, contributes to age-related cardiovascular disease (CVD) and other aging-related pathologies. Humans with a heterozygous loss-of-function SERPINE1 variant exhibit protection against aging and cardiometabolic dysfunction. We engineered a mouse model mimicking the human mutation (Serpine1TA700/+) and compared cardiovascular responses with WT littermates. Serpine1TA700/+ mice lived 17% …
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