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JCI Insight Glucosamine links hyperglycemia to mTORC1 activation and glucose toxicity in diabetes
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JCI Insight Glucosamine links hyperglycemia to mTORC1 activation and glucose toxicity in diabetes
Hyperglycemia is a principal driver of β cell failure and multiple-organ complications in diabetes. Chronic exposure to hyperglycemia overstimulates mTORC1, disrupting glucose metabolism and promoting ER stress, oxidative stress, and inflammation; however, the upstream metabolic signal(s) linking glucose to mTORC1 activation remains unclear. Here, we identified glucosamine as a key metabolite connecting elevated glucose to mTORC1 signaling in pa…
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