How to bet San Francisco 49ers in 2025: Super Bowl odds, win total, props, best bets and what you need to know

How to bet San Francisco 49ers in 2025: Super Bowl odds, win total, props, best bets and what you need to know

We dive into the San Francisco 49ers' 2025 NFL odds, review their offseason and preview their season from a betting perspective

Cardinals, Rams, 49ers, Seahawks: 2025 NFL Team Previews NFC West

NFC West This time last year, the San Francisco 49ers were odds-on favorites (-200) to win the NFC West coming off a defeat in Super Bowl LVIII. Injuries got the season off track before it began, as Christian McCaffrey did not debut until Week 10 when the 49ers got off to a sluggish 5-4 start. McCaffrey only played four games and finished the season on Injured Reserve along with 18 others, including several starters. The 49ers finished at the bo…

Opponent offseason update: Seattle Seahawks

The Seattle Seahawks are gearing up for the 2025 season with significant roster changes and new additions. Key signings include quarterback Sam Darnold and wide receiver Cooper Kupp, while notable trades saw Geno Smith and DK Metcalf leave the team. The Seahawks hope to leverage their retained defensive talent while aiming to enhance their offensive game under new coordinator Klint Kubiak. They last played the Panthers in 2023, where Seattle sec…