How Does Narcan Work? How It Reverses Opioid Overdose Can Provide a Molecular Blueprint for More Effective Drugs

How does Narcan work? How it reverses opioid overdose can provide a molecular blueprint for more effective drugs

Naloxone, also known by the brand name Narcan, is one of the most important drugs in the United States' fight against the opioid crisis. It reverses an opioid overdose nearly instantly, restarting breathing in a person who was unresponsive moments before and on the brink of death. To bystanders witnessing it being administered, naloxone can appear almost supernatural.

How does Narcan work? Mapping how it reverses opioid overdose can provide a molecular blueprint for more effective drugs

Naloxone competes with opioids for the same receptor on the surface of neurons. Matt Rourke/AP PhotoNaloxone, also known by the brand name Narcan, is one of the most important drugs in the United States’ fight against the opioid crisis. It reverses an opioid overdose nearly instantly, restarting breathing in a person who was unresponsive moments before and on the brink of death. To bystanders witnessing it being administered, naloxone can appear…

How does Narcan work? Mapping how it reverses opioid overdose can provide a molecular blueprint for more effective drugs

Naloxone, also known by the brand name Narcan, is one of the most important drugs in the United States’ fight against the opioid crisis. It reverses an opioid overdose nearly instantly, restarting breathing in a person who was unresponsive moments before and on the brink of death. To bystanders witnessing it being administered, naloxone can appear almost supernatural. Although the Food and Drug Administration approved naloxone for medical use in…