US EditionGLP-1 drugs may fight addiction across every major substance, according to a study of 600,000 people
Study of over 600,000 U.S. veterans with type 2 diabetes finds GLP-1 drugs reduce risk of new substance use disorders by up to 25%, also lowering overdose and death rates.
- On March 4, a BMJ analysis of U.S. Department of Veterans Affairs electronic health records found GLP-1 use tied to lower risk of substance use disorders in 606,434 U.S. veterans with type 2 diabetes.
- Researchers pursued the question after patient reports and animal studies suggested GLP-1 receptors cluster in brain reward circuitry and GLP-1 drugs reduce craving.
- In patients already with addictions, GLP-1 use was linked to 50% fewer deaths, 39% fewer overdoses, and roughly 12 fewer serious events per 1,000 people over three years.
- While not approved for addiction, randomized clinical trials are underway and researchers say, if confirmed, effects could close treatment gaps and benefit millions of GLP-1 users.
- The study has limits: it was observational within the VA health system population, mostly older, white, male, with unmeasured confounding and comparator choice; randomized controlled trials are needed to confirm causality.
94 Articles
94 Articles
GLP-1 medications might fight addiction; what to know
A new study finds that popular GLP-1 drugs used to treat diabetes and obesity show new promise in fighting multiple substance use disorders. An analysis of electronic health records of more than 600,000 U.S. veterans with diabetes found that users…
GLP-1 Drugs May Prevent, Treat Multiple Addictions
(MedPage Today) -- Initiation of a GLP-1 receptor agonist was tied to lower risks of several substance use disorders (SUDs) in adults with type 2 diabetes, according to a target trial emulation using data on veterans. In patients without a history...
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