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Colorectal Cancer Now Top Cause of Cancer Deaths for Americans Under 50

Colorectal cancer deaths in Americans under 50 rose 1.1% annually since 2005 while overall cancer deaths dropped 44%, researchers say.

  • On Thursday, a JAMA study found colorectal cancer is now the leading cause of cancer deaths among people younger than 50 in the United States.
  • Researchers led by Rebecca Siegel analyzed National Cancer Institute data from nearly 1.3 million deaths under age 50 and found cancer death rates fell 44% despite rising colorectal deaths.
  • Analyzing trends, the study found colorectal cancer deaths increased a little over 1% annually between 1990 and 2023, the only cause to rise while lung, leukemia, and breast cancer deaths declined.
  • Experts urge people 45–49 to get screened as only 37% of adults ages 45 to 49 are up-to-date and half of under-50 diagnoses occur in this group.
  • Amid unclear causes, researchers call for more study as MD Anderson's Dr. Y. Nancy You called the findings `timely` and a `red flag`, urging to `double down` on work to pinpoint causes.
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Jenna Scott recalls the joy of being pregnant with her first and only child. She also recalls the intense abdominal pain.

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gwhospital.com broke the news in on Monday, January 19, 2026.
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