Carrageenan-based multi-unit spheroidal tablets for fenofibric acid: A strategy to minimize food effect via mucoadhesive gel interfaces

Carrageenan-based multi-unit spheroidal tablets for fenofibric acid: A strategy to minimize food effect via mucoadhesive gel interfaces

Abstract Fenofibric acid (FA), the active metabolite of fenofibrate, is a potent lipid-modifying agent whose clinical effectiveness is often compromised by pronounced food effects, resulting in variable systemic exposure. In this study, we developed a novel carrageenan-based multi-unit spheroidal tablet (MUST) formulation designed to mitigate the impact of prandial state on FA pharmacokinetics. The matrix system utilized an optimized κ-/ι-carrag…