Published 3 years ago

An omega-3 that's poison for tumors

Summary by Eurek Alert

3D tumors that disintegrate within a few days thanks to the action of a well-known omega-3 (DHA, found mainly in fish) -- this is the exceptional discovery by University of Louvain researchers. Hungry for fatty acids, tumor cells in acidosis gorge themselves on DHA but are unable to store it correctly and literally poison themselves. The result? They die.

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Eurek Alert

An omega-3 that's poison for tumors

3 years ago·Washington, United States

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News Medical

Study elucidates how Omega-3 fatty acids poison tumor cells

So-called "good fatty acids" are essential for human health and much sought after by those who try to eat healthily. Among the Omega-3 fatty acids, DHA or docosahexaenoic acid is crucial to brain function, vision and the regulation of inflammatory phenomena.

3 years ago·United States

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Sci Tech Daily

An Omega-3 That’s Poison for Cancer Tumors

3 years ago

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ScienceDirect

Peroxidation of n-3 and n-6 polyunsaturated fatty acids in the acidic tumor environment leads to ferroptosis-mediated anticancer effects

Tumor acidosis promotes disease progression through a stimulation of fatty acid (FA) metabolism in cancer cells. Instead of blocking the use of FAs by…

3 years ago·Amsterdam, Netherlands

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www.springer.com

Long-chain omega-3 polyunsaturated fatty acids decrease mammary tumor growth, multiorgan metastasis and enhance survival

Epidemiological studies show a reduced risk of breast cancer (BC) in women consuming high levels of long-chain (LC) omega-3 (ω-3) fatty acids (FAs) compared with women who consumed low levels. However, the regulatory and mechanistic roles of dietary ω-6 and LC-ω-3 FAs on tumor progression, metastasis and survival are poorly understood. Female BALB/c mice (10-week old) were pair-fed with a diet containing ω-3 or an isocaloric, isolipidic ω-6 diet…

3 years ago·United States

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Neuroscience News

An Omega-3 That's Poison for Tumors

Commonly associated with helping improve brain function, the omega 3 fatty acid DHA may have another, previously unknown benefit. A new study reports DHA and other related fatty acids may help slow the development of cancerous tumors.

3 years ago

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