US EditionSustained HIV-1 Remission After Heterozygous CCR5Δ32 Stem Cell Transplantation
A male patient achieved over six years of HIV remission after stem cell transplant without CCR5Δ32 homozygosity, highlighting viral reservoir reduction as key, researchers say.
- In a Nature early‑access report, a heterozygous CCR5 wild‑type/Δ32 male patient known as Berlin 2 received an HLA‑matched unrelated allo‑SCT to treat acute myeloid leukemia.
- Evidence points to reservoir depletion after allogeneic stem‑cell transplant , with researchers linking remission to viral reservoir reduction rather than donor CCR5Δ32 homozygosity.
- Reservoir testing revealed intact proviral HIV pre‑transplant but no replication‑competent virus in blood and intestinal tissues post-allo‑SCT, with declining HIV‑specific antibodies and T cells and high antibody‑dependent cellular cytotoxicity at transplantation.
- Given that cures are extremely rare, documented HIV cures remain limited to six cases, researchers caution the CCR5Δ32 stem-cell procedure won't become standard while authors say it could inform pharmaceutical treatments and gene editing.
- Other transplant cases both support and challenge the mechanism, as the Geneva patient supports graft‑versus‑reservoir response while two Boston patients experienced viral rebound.
13 Articles
13 Articles
A 60-year-old German HIV patient has achieved a 'sustained remission' of the disease - which can be considered cured - after undergoing a stem cell transplant to treat leukemia.The case, documented and published this Monday by the scientific journal Nature, is the seventh documented referral of the virus that causes AIDS worldwide.According to the text of the study, the patient discontinued his antiretroviral therapy (ART) against HIV to undergo…
Eldiario.es
elDiarioARThe man, 60 years old, was a carrier of HIV and developed a leukemia for which he received a stem cell transplant with a mutation that protects against AIDS; six years after the transplant, there is no trace of the virus in his bodyHemeroteca - The taboo of being children of parents who died from HIV: “You end up lying and turning to cancer before AIDS” In 2010, doctors presented to the world the case of Timothy Ray Brow, known since then as the…
7th HIV Remission Raises Hope of Long-Lasting Treatment For More People
A German man remains in remission from HIV an incredible six years after he received a stem cell transplant to treat an aggressive form of leukemia. The seventh known HIV patient to achieve long-term remission, the patient known as Berlin 2 (B2), received donor stem cells containing only one copy of a mutated gene known to confer resistance to HIV, unlike the two copies present in donor cells given to other patients. The single-copy cells were t…
Sustained HIV-1 remission after heterozygous CCR5Δ32 stem cell transplantation
HIV cure is exceptionally rare, documented in only six cases among the estimated 88 million individuals who have acquired HIV since the epidemic's onset1–6. Successful cures, including the pioneering Berlin patient, are limited to individuals receiving allogeneic stem cell transplants (allo-SCT) for hematological cancers. HIV resistance from stem cell donors with the rare homozygous CCR5 Δ32 mutation was long considered the main mechanism for HI…
A medical breakthrough gives hope to people living with the human immunodeficiency virus (HIV) worldwide, as a 60-year-old German patient with leukemia and that virus managed to stay more than six years without viral rebound after receiving a stem cell transplant. According to Nature magazine, this is the seventh documented case in the world. The patient stopped antiretroviral therapy three years after the transplant and, six years later, resear…
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