Nature of epigenetic aging from a single-cell perspective

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Nature of epigenetic aging from a single-cell perspective

Age-related changes in DNA methylation (DNAm) form the basis of the most robust predictors of age—epigenetic clocks—but a clear mechanistic understanding of exactly which aspects of aging are quantified by these clocks is lacking. Here, to clarify the nature of epigenetic aging, we juxtapose the dynamics of tissue and single-cell DNAm in mice. We compare these changes during early development with those observed during adult aging in mice, and c…